Publications

 

2024

- B. Mir, I. Serrano-Chacón, P. Medina, V. Macaluso, M. Terrazas, A. Gandioso, M. Garavís, Modesto Orozco,* Núria Escaja,* and Carlos González*. Site-Specific Incorporation of a Fluorescent Nucleobase Analog Enhances I-Motif Stability and allows Monitoring its Folding Inside the Cell. Nucleic Acids Res., in press, 2024. http://doi.org/10.1093/nar/gkae106

- M. Garavís, P. J. B. Edwards, I. Serrano-Chacón, O. Doluca, V. V. Filichev* and C. González*. Understanding Intercalative Modulation of G-Rich Sequence Folding: Solution Structure of a TINA-Conjugated Antiparallel DNA Triplex. Nucleic Acids Res., in press, 2024. http://doi.org/10.1093/nar/gkae028

- P. Víšková, E. Ištvánková, J. Ryneš, Š. Džatko, T. Loja, M. L. Živković, R. Rigo, R. El-Khoury, I. Serrano-Chacón, M. J. Damha, C. González, J.-L. Mergny, S. Foldynová-Trantírková and L. Trantírek. DNA i-motif levels are overwhelmingly depleted in living human cells: insights from in-cell NMR. Nat. Comm., 15:1992, 2024. http://doi.org/10.1038/s41467-024-46221-y

 

2023

- I. Serrano-Chacón, B. Mir, L. Cupellini, F. Colizzi, M. Orozco,* N. Escaja,* C. González*. pH-dependent capping interactions induce large-scale structural transitions in i-motifs. J. Am. Chem. Soc., 145, 3696−3705, 2023. http://doi.org/10.1021/jacs.2c13043

- V. Genna, J. Iglesias-Fernández, L. Reyes-Fraile, N. Villegas, K. Guckian, P. Seth, B. Wan, C. Cabrero, M. Terrazas, I. Brun-Heath, C. González, S. Sciabola, A. Villalobos, M. Orozco. Controlled Sulfur-Based Engineering Confers Mouldability to Phosphorothioate Antisense Oligonucleotides. Nucleic Acids Res., 51, 4713–4725, 2023. http://doi.org/10.1093/nar/gkad309

- R. El-Khoury, V. Macaluso, C. Hennecker, A. K. Mittermaier, M. Orozco, C. González, M. Garavís*, M. J. Damha*. I-Motif folding intermediates with zero-nucleotide loops are trapped by 2′-fluoroarabinocytidine via F···H and O···H hydrogen bonds. Communications Chemistry, 6:31, 2023. http://doi.org/10.1038/s42004-023-00831-7

 

2022

- N. Escaja*, B. Mir, M. Garavís, C. González*. Non-G base tetrads. Molecules, 27, 5287, 2022. http://doi.org/10.3390/molecules27165287

- L. Díaz-Casado, A. G. Santana, I. Gómez-Pinto, F. Corzana, J. Jiménez-Barbero, C. González, J. L. Asensio*. Binding-driven reactivity attenuation enables identification of selective drug candidates: an innovative NMR-based screening strategy for Nucleic Acid targets. Communications Chemistry, 5:137, 2022.  http://doi.org/10.1038/s42004-022-00755-8

- A. V. Aralov, N. Gubina, C. Cabrero, V.B. Tsvetkov, A.V. Turaev, B. I. Fedeles, R. G. Croy, E. A. Isaakova, D. Melnik, S. Dukova, D. Y. Ryazantsev, A. A. Khrulev1, A. Varizhuk, C. González, T. S. Zatsepin, and J. M. Essigmann. The Impact of the 7,8-Dihydro-8-oxo-1,N6-ethenoadenine – an exclusively Hoogsteen paired thymine mimic in DNA that induces A  T transversions in Escherichia coli. Nucleic Acids Res., 50(6), 3056-3069, 2022. http://doi.org/10.1093/nar/gkac148

- C. Pinto-Díez, R. Ferreras-Martín, R. Carrión-Marchante, JI. Klett-Mingo, M. García-Hernández, MI. Pérez-Morgado, S. Sacristán, M. Barragán, M. Seijo-Vila, I. Tundidor, S. Blasco-Benito, E. Pérez-Gómez, I. Gómez-Pinto, C. Sánchez , C. González, VM. González, ME. Martín*. An optimized MNK1b aptamer, apMNKQ2, and its potential use as a therapeutic agent in breast cancer. Molecular Therapy - Nucleic Acids, 30, 553-568, 2022. http://doi.org/10.1016/j.omtn.2022.11.009

 

2021

- I. Serrano-Chacón, B. Mir, N. Escaja*, and C. González*. The structure of i-motif/duplex junctions at neutral pH. J. Am. Chem. Soc., 143, 12919–12923, 2021. http://doi.org/10.1021/jacs.1c04679

- C. Cabrero, N. Martín-Pintado, S. Mazzini, R. Gargallo, R. Eritja, A. Aviñó,* and C. González.* Structural effects of incorporation of 2´-deoxy-2´2´-difluorodeoxycytidine (gemcitabine) in A- and B-form duplexes. Chem. Eur. J., 27, 7351–7355, 2021. http://doi.org/10.1002/chem.202100503

- L. Díaz-Casado, I. Serrano-Chacón, L. Montalvillo-Jiménez, F. Corzana, A. Bastida, A.G. Santana, C. González,* J.L. Asensio.* Selective recognition of Quadruplex-Duplex Junctions: Targeting the G4 Hot-Spot. Chem. Eur. J., 27, 6204–6212, 2021. http://doi.org/10.1002/chem.202005026

- F. Battistini, P. D. Dans, M. Terrazas, C.L. Castellazzi, G. Portella, M. Labrador, N. Villegas, I. Brun-Heath, C. González and M. Orozco*. The Impact of the HydroxyMethylCytosine epigenetic signature on DNA structure and function. PLoS Comput. Biol, 17(11): e1009547, 2021. http://doi.org/10.1371/journal.pcbi.1009547

- V. Sánchez-Martín, D.A. Schneider, M. Ortiz-González, A. Soriano-Lerma, A. Linde-Rodriguez, V. Perez-Carrasco, J. Gutierrez-Fernández, M. Cuadros, J.C. Morales, C. González, M. Soriano, J.A. Garcia-Salcedo. Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA Polymerase I inhibitors for colorectal cancer treatment. Cell Chem. Biol. 28, 1590–1601, 2021. http://doi.org/10.1016/j.chembiol.2021.05.021

- E. Belmonte-Reche, I. Serrano-Chacón, C. González, J. Gallo, M. Bañobre-López. Potential G-quadruplexes and i-Motifs in the SARS-CoV-2. PLoS ONE, 16(6): e0250654, 2021. http://doi.org/10.1371/journal.pone.0250654


2020

- B.P. Paudel, A.L. Moye, H. Abou-Assi, R. El-Khoury, S.B. Cohe, M. L. Birrento, S. Samosorn, K. Intharapichai, C.G. Tomlinson, MP. Teulade-Fichou, C. González, J. L. Beck, M.J. Damha, A.M. van Oijen, and T.M. Bryan. A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution. elife, 9, e56428, 2020. http://doi.org/10.7554/eLife.56428

- R. J. Roach, M. Garavís, C. González, G. B. Jameson, V. V. Filichev and T. K. Hale. Heterochromatin Protein 1α interacts with parallel RNA and DNA G- quadruplexes. Nucleic Acids Res., 48, 682-693, 2020. http://doi.org/10.1093/nar/gkz1138

 

2018

- H. Abou-Assi, M. Garavís, C. González,* and M. J. Damha*. i-Motif DNA – Structural Features and Significance to Cell Biology. Nucleic Acids Res., 46(16), 8038-8056, 2018. http://doi.org/10.1093/nar/gky735

- I. Gutiérrez, M. Garavís, S. de Lorenzo, A. Villasante, C. González, and J. R. Arias-Gonzalez. Single-stranded Condensation Stochastically Blocks G-quadruplex Assembly in Human Telomeric RNA. J. Phys. Chem. Lett., 9, 2498−2503, 2018. http://doi.org/10.1021/acs.jpclett.8b00722

- E. Vengut-Climent, P. Peñalver, R. Lucas, I. Gómez-Pinto, A. Aviñó, A. M. Muro-Pastor, E. Galbis, M. Violante de Paz, C. F. Guerra, F. M. Bickelhaupt, R. Eritja C. González and J. C. Morales. Glucose-Nucleobase Pairs within DNA: Impact of Hydrophobicity, Alternative Linking Unit and DNA Polymerase Nucleotide Insertion Studies. Chem. Sci., 9(14), 3544-3554, 2018 http://doi.org/10.1039/C7SC04850E

- M. Habibian, M. Yahyaee-Anzahaee, M. Lucic, E. Moroz, N. Martın-Pintado, L. D. Giovani, J.C. Leroux, J. Hall, C. González, and M. J. Damha. Structural properties and gene-silencing activity of chemically modified DNA-RNA Hybrids with parallel orientation. Nucleic Acids Res., i46, 1614-1623, 2018. http://doi.org/10.1093/nar/gky024

- H. Abou-Assi, Y. Chen Lin, I. Serrano, C. González,* and M. J. Damha*. Probing synergistic effects of DNA methylation and 2'β-fluorination on i-motif stability. Chemistry-A Eur. J., 24, 471-477, 2018. http://doi.org/10.1002/chem.201704591

 

2017

- B. Mir, I. Serrano, D. Buitrago, M. Orozco, N. Escaja*, and C. González*. 2'- Prevalent sequences in the human genome can form mini i-motifs structures at physiological pH. J. Am Chem Soc., 139, 13985-13988, 2017. http://doi.org/10.1021/jacs.7b07383

- H. Abou-Assi, R. El-Khoury, C. González* and M. J. Damha*. 2'-Fluoroarabinonucleic Acid Modification Traps G-quadruplex and i-Motif Structures in Human Telomeric DNA. Nucleic Acids Res., 20, 11535-11546, 2017. http://doi.org/10.1093/nar/gkx838

- A. Aviñó, M. Dellafiore, R. Gargallo, C. González, A. M. Iribarren, J. Montserrat and R. Eritja. Stabilization of telomeric i-motif structures by (2'S)-2'-deoxy-2'-C-methyl-cytidine residues. ChemBioChem, 18, 1123-1128, 2017. http://doi.org/10.1002/cbic.201700112

- S. Benabou, A. Aviñó, S. Lyonnais, C. González, R. Eritja, and R. Gargallo. I-motif structures in long cytosine-rich sequences found upstream of the promoter region of the SMARCA4 gene. Biochimie, 140, 20-33, 2017. http://dx.doi.org/10.1016/j.biochi.2017.06.005

- B. Mir, X. Solés, C. González*, and N. Escaja*. The effect of the neutral cytidine protonated analogue pseudoisocytidine on the stability of i-motif structures. Sci. Rep., 7, 2772, 2017. http://doi.org/10.1038/s41598-017-02723-y

- J. Lietard, H. Abou-Assi, I. Gómez-Pinto, C. González, M. M. Somoza, and  M. J. Damha, Mapping the Affinity Landscape of Thrombin-binding Aptamers on 2'F-ANA/DNA Chimeric G-Quadruplex Microarrays, Nucleic Acids Res., 45, 1619-1632, 2017.http://doi.org/10.1093/nar/gkw1357.

- P. D. Dans, I. Ivani, A. Hospital, G. Portella, C. González*, and Modesto Orozco*. How Accurate Are Accurate Dorece-Fields for DNA?. Nucleic Acids Res., 45 (7): 4217-4230, 2017. http://doi.org/10.1093/nar/gkw1355 

 

2016

- E. Vengut-Climent, I. Gomez-Pinto, R. Lucas, P. Penalver, A. Avino, C. F. Guerra, F. M. Bickelhaupt, R. Eritja, C. González and J. C. Morales, Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA, Angew. Chem. Int. Ed., 55, 8643-8647, 2016. http://doi.org/10.1002/anie.201603510.

- E. Jimenez-Moreno, L. Montalvillo-Jimenez, A. G. Santana, A. M. Gomez, G. Jimenez-Oses, F. Corzana, A. Bastida, J. Jimenez-Barbero, F. J. Canada, I. Gomez-Pinto, C. González and J. L. Asensio, Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders, J. Am. Chem. Soc., 138, 6463-6474, 2016. http://doi.org/10.1021/jacs.6b00328.

- I. Ivani, P. D. Dans, A. Noy, A. Perez, I. Faustino, A. Hospital, J. Walther, P. Andrio, R. Goni, A. Balaceanu, G. Portella, F. Battistini, J. Lluis Gelpi, C. González, M. Vendruscolo, C. A. Laughton, S. A. Harris, D. A. Case and M. Orozco, Parmbsc1: a refined force field for DNA simulations, Nat Methods, 13, 55-58, 2016. http://doi.org/10.1038/nmeth.3658.

- S. Benabou, M. Garavis, S. Lyonnais, R. Eritja, C. González and R. Gargallo, Understanding the effect of the nature of the nucleobase in the loops on the stability of the i-motif structure, Phys. Chem. Chem. Phys, 18, 7997-8004, 2016. http://doi.org/10.1039/c5cp07428b.

- H. Abou Assi, R. W. Harkness, N. Martin-Pintado, C. J. Wilds, R. Campos-Olivas, A. K. Mittermaier, C. González and M. J. Damha, Stabilization of i-motif structures by 2 '-beta-fluorination of DNA, Nucleic Acids Res., 44, 4998-5009, 2016. http://doi.org/10.1093/nar/gkw402. 

2015

- G. Rossetti, P. D. Dans, I. Gomez-Pinto, I. Ivani, C. González and M. Orozco, The structural impact of DNA mismatches, Nucleic Acids Res., 43, 4309-4321, 2015. http://doi.org/10.1093/nar/gkv254.

- G. Portella, M. Terrazas, N. Villegas, C. González and M. Orozco, Can A Denaturant Stabilize DNA? Pyridine Reverses DNA Denaturation in Acidic pH, Angew. Chem. Int. Ed., 54, 10488-10491, 2015. http://doi.org/10.1002/anie.201503770.

- S. Perez-Rentero, R. Gargallo, C. González and R. Eritja, Modulation of the stability of i-motif structures using an acyclic threoninol cytidine derivative, Rsc Advances, 5, 63278-63281, 2015. http://doi.org/10.1039/c5ra10096h.

- S. Martinez-Montero, G. F. Deleavey, N. Martin-Pintado, J. F. Fakhoury, C. González and M. J. Damha, Locked 2 '-Deoxy-2 ',4 '-Difluororibo Modified Nucleic Acids: Thermal Stability, Structural Studies, and siRNA Activity, ACS Chem. Biol., 10, 2016-2023, 2015. http://doi.org/10.1021/acschembio.5b00218.

- S. Martinez-Montero, G. F. Deleavey, A. Dierker-Viik, P. Lindovska, T. Ilina, G. Portella, M. Orozco, M. A. Parniak, C. González and M. J. Damha, Synthesis and Properties of 2 '-Deoxy-2 ',4 '-difluoroarabinose-Modified Nucleic Acids, J. Org. Chem., 80, 3083-3091, 2015. http://doi.org/10.1021/jo502948t.

- M. Garavis, M. Mendez-Lago, V. Gabelica, S. L. Whitehead, C. González and A. Villasante, The structure of an endogenous Drosophila centromere reveals the prevalence of tandemly repeated sequences able to form i-motifs, Sci. Rep., 5, 2015. http://doi.org/10.1038/srep13307.

- M. Garavis, N. Escaja, V. Gabelica, A. Villasante and C. González, Centromeric Alpha-Satellite DNA Adopts Dimeric i-Motif Structures Capped by AT Hoogsteen Base Pairs, Chem. Eur. J., 21, 9816-9824, 2015. http://doi.org/10.1002/chem.201500448.

- O. Doluca, J. M. Withers, T. S. Loo, P. J. B. Edwards, C. González and V. V. Filichev, Interdependence of pyrene interactions and tetramolecular G4-DNA assembly, Org. Biomol. Chem., 13, 3742-3748, 2015. http://doi.org/10.1039/c4ob02499k. 

2014

- G. Artigas, P. Lopez-Senin, C. González, N. Escaja and V. Marchan, Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing, Org. Biomol. Chem., 13, 452-464, 2015. http://doi.org/10.1039/c4ob01925c.

- M. Mompean, C. González, E. Lomba and D. V. Laurents, Combining Classical MD and QM Calculations to Elucidate Complex System Nucleation: A Twisted, Three-Stranded, Parallel beta-Sheet Seeds Amyloid Fibril Conception, J. Phys. Chem. B, 118, 7312-7316, 2014. http://doi.org/10.1021/jp503742p.

- S. Martinez-Montero, G. F. Deleavey, A. Kulkarni, N. Martin-Pintado, P. Lindovska, M. Thomson, C. González, M. Goette and M. J. Damha, Rigid 2 ',4 '-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase, J. Org. Chem., 79, 5627-5635, 2014. http://doi.org/10.1021/jo500794v.

- R. Lucas, P. Penalver, I. Gomez-Pinto, E. Vengut-Climent, L. Mtashobya, J. Cousin, O. S. Maldonado, V. Perez, V. Reynes, A. Avino, R. Eritja, C. González, B. Linclau and J. C. Morales, Effects of Sugar Functional Groups, Hydrophobicity, and Fluorination on Carbohydrate-DNA Stacking Interactions in Water, J. Org. Chem., 79, 2419-2429, 2014. http://doi.org/10.1021/jo402700y.

- M. Garavis, B. Lopez-Mendez, A. Somoza, J. Oyarzabal, C. Dalvit, A. Villasante, R. Campos-Olivas and C. González, Discovery of Selective Ligands for Telomeric RNA G-quadruplexes (TERRA) through F-19-NMR Based Fragment Screening, ACS Chem. Biol., 9, 1559-1566, 2014. http://doi.org/10.1021/cb500100z.

- O. Doluca, T. K. Hale, P. J. B. Edwards, C. González and V. V. Filichev, Assembly Dependent Fluorescence Enhancing Nucleic Acids in Sequence-Specific Detection of Double-Stranded DNA, Chempluschem, 79, 58-66, 2014. http://doi.org/10.1002/cplu.201300310.

- S. Benabou, R. Ferreira, A. Avino, C. González, S. Lyonnais, M. Sola, R. Eritja, J. Jaumot and R. Gargallo, Solution equilibria of cytosine- and guanine-rich sequences near the promoter region of the n-myc gene that contain stable hairpins within lateral loops, Biochimica et biophysica acta, 1840, 41-52, 2014. http://doi.org/10.1016/j.bbagen.2013.08.028.

- S. Benabou, A. Avino, R. Eritja, C. González and R. Gargallo, Fundamental aspects of the nucleic acid i-motif structures, Rsc Advances, 4, 26956-26980, 2014. http://doi.org/10.1039/c4ra02129k. 

2013

- A. G. Santana, E. Jimenez-Moreno, A. M. Gomez, F. Corzana, C. González, G. Jimenez-Oses, J. Jimenez-Barbero and J. Luis Asensio, A Dynamic Combinatorial Approach for the Analysis of Weak Carbohydrate/Aromatic Complexes: Dissecting Facial Selectivity in CH/pi Stacking Interactions, J. Am. Chem. Soc., 135, 3347-3350, 2013. http://doi.org/10.1021/ja3120218.

- N. Martin-Pintado, M. Yahyaee-Anzahaee, G. F. Deleavey, G. Portella, M. Orozco, M. J. Damha and C. González, Dramatic Effect of Furanose C2 ' Substitution on Structure and Stability: Directing the Folding of the Human Telomeric Quadruplex with a Single Fluorine Atom, J. Am. Chem. Soc., 135, 5344-5347, 2013. http://doi.org/10.1021/ja401954t.

- N. Martin-Pintado, G. F. Deleavey, G. Portella, R. Campos-Olivas, M. Orozco, M. J. Damha and C. González, Backbone FC-H center dot center dot center dot O Hydrogen Bonds in 2 ' F-Substituted Nucleic Acids, Angew. Chem. Int. Ed., 52, 12065-12068, 2013. http://doi.org/10.1002/anie.201305710.

- E. Jimenez-Moreno, I. Gomez-Pinto, F. Corzana, A. G. Santana, J. Revuelta, A. Bastida, J. Jimenez-Barbero, C. González and J. Luis Asensio, Chemical Interrogation of Drug/RNA Complexes: From Chemical Reactivity to Drug Design, Angew. Chem. Int. Ed., 52, 3148-3151, 2013. http://doi.org/10.1002/anie.201209434.

- A. Hospital, I. Faustino, R. Collepardo-Guevara, C. González, J. Lluis Gelpi and M. Orozco, NAFlex: a web server for the study of nucleic acid flexibility, Nucleic Acids Res., 41, W47-W55, 2013. http://doi.org/10.1093/nar/gkt378.

- I. Gomez-Pinto, E. Vengut-Climent, R. Lucas, A. Avino, R. Eritja, C. González and J. Carlos Morales, Carbohydrate-DNA Interactions at G-Quadruplexes: Folding and Stability Changes by Attaching Sugars at the 5'-End, Chem. Eur. J., 19, 1920-1927, 2013. http://doi.org/10.1002/chem.201203902.

- M. Garavis, C. González and A. Villasante, On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution, Genome biology and evolution, 5, 1142-50, 2013. http://doi.org/10.1093/gbe/evt079.

- M. Garavis, R. Bocanegra, E. Herrero-Galan, C. González, A. Villasante and J. R. Arias-González, Mechanical unfolding of long human telomeric RNA (TERRA), Chem. Commun., 49, 6397-6399, 2013. http://doi.org/10.1039/c3cc42981d.

- N. Escaja, I. Gomez-Pinto, J. Viladoms, E. Pedroso and C. González, The effect of loop residues in four-stranded dimeric structures stabilized by minor groove tetrads, Org. Biomol. Chem., 11, 4804-4810, 2013. http://doi.org/10.1039/c3ob40741a. 

2012

- N. Martin-Pintado, M. Yahyaee-Anzahaee, R. Campos-Olivas, A. M. Noronha, C. J. Wilds, M. J. Damha and C. González, The solution structure of double helical arabino nucleic acids (ANA and 2 ' F-ANA): effect of arabinoses in duplex-hairpin interconversion, Nucleic Acids Res., 40, 9329-9339, 2012. http://doi.org/10.1093/nar/gks672.

- R. Lucas, E. Vengut-Climent, I. Gomez-Pinto, A. Avino, R. Eritja, C. González and J. C. Morales, Apolar carbohydrates as DNA capping agents, Chem. Commun., 48, 2991-2993, 2012. http://doi.org/10.1039/c2cc17093k.

- R. Ferreira, M. Alvira, A. Avino, I. Gomez-Pinto, C. González, V. Gabelica and R. Eritja, Synthesis and Structural Characterization of Stable Branched DNA G-Quadruplexes Using the Trebler Phosphoramidite, Chemistryopen, 1, 106-114, 2012. http://doi.org/10.1002/open.201200009.

- N. Escaja, J. Viladoms, M. Garavis, A. Villasante, E. Pedroso and C. González, A minimal i-motif stabilized by minor groove G:T:G:T tetrads, Nucleic Acids Res., 40, 11737-47, 2012. http://doi.org/10.1093/nar/gks911.

- F. Diez-Garcia, I. Gomez-Pinto, A. Chakrabartty, C. González and D. V. Laurents, Conformation specificity and arene binding in a peptide composed only of Lys, Ile, Ala and Gly, European Biophysics Journal with Biophysics Letters, 41, 63-72, 2012. http://doi.org/10.1007/s00249-011-0758-4.

- F. Diez-Garcia, A. Chakrabartty, C. González and D. V. Laurents, An Arg-rich putative prebiotic protein is as stable as its Lys-rich variant, Archives of Biochemistry and Biophysics, 528, 118-126, 2012. http://doi.org/10.1016/j.abb.2012.09.006.

- F. Barragan, D. Carrion-Salip, I. Gomez-Pinto, A. González-Canto, P. J. Sadler, R. de Llorens, V. Moreno, C. González, A. Massaguer and V. Marchan, Somatostatin Subtype-2 Receptor-Targeted Metal-Based Anticancer Complexes, Bioconjugate Chem., 23, 1838-1855, 2012. http://doi.org/10.1021/bc300173h. 

2011

- J. Luis Asensio, L. Perez-Lago, J. M. Lazaro, C. González, G. Serrano-Heras and M. Salas, Novel dimeric structure of phage phi 29-encoded protein p56: insights into uracil-DNA glycosylase inhibition, Nucleic Acids Res., 39, 9779-9788, 2011. http://doi.org/10.1093/nar/gkr667.

- R. Lucas, I. Gomez-Pinto, A. Avino, J. J. Reina, R. Eritja, C. González and J. C. Morales, Highly Polar Carbohydrates Stack onto DNA Duplexes via CH/pi Interactions, J. Am. Chem. Soc., 133, 1909-1916, 2011. http://doi.org/10.1021/ja108962j. 

2010

- J. K. Watts, N. Martin-Pintado, I. Gomez-Pinto, J. Schwartzentruber, G. Portella, M. Orozco, C. González and M. J. Damha, Differential stability of 2 ' F-ANA.RNA and ANA.RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility, Nucleic Acids Res., 38, 2498-2511, 2010. http://doi.org/10.1093/nar/gkp1225.

- J. Viladoms, N. Escaja, E. Pedroso and C. González, Self-association of cyclic oligonucleotides through G:T:G:T minor groove tetrads, Biorg. Med. Chem., 18, 4067-4073, 2010. http://doi.org/10.1016/j.bmc.2010.04.018.

- T. Vacas, F. Corzana, G. Jimenez-Oses, C. González, A. M. Gomez, A. Bastida, J. Revuelta and J. Luis Asensio, Role of Aromatic Rings in the Molecular Recognition of Aminoglycoside Antibiotics: Implications for Drug Design, J. Am. Chem. Soc., 132, 12074-12090, 2010. http://doi.org/10.1021/ja1046439.

- J. Revuelta, T. Vacas, F. Corzana, C. González, A. Bastida and J. Luis Asensio, Structure-Based Design of Highly Crowded Ribostamycin/Kanamycin Hybrids as a New Family of Antibiotics, Chem. Eur. J, 16, 2986-2991, 2010. http://doi.org/10.1002/chem.200903003.

- J. Pedro Lopez-Alonso, M. Bruix, J. Font, M. Ribo, M. Vilanova, M. Angeles Jimenez, J. Santoro, C. González and D. V. Laurents, NMR Spectroscopy Reveals that RNase A is Chiefly Denatured in 40% Acetic Acid: Implications for Oligomer Formation by 3D Domain Swapping, J. Am. Chem. Soc., 132, 1621-1630, 2010. http://doi.org/10.1021/ja9081638.

- J. P. Lopez-Alonso, M. A. Pardo-Cea, I. Gomez-Pinto, I. Fernandez, A. Chakrabartty, E. Pedroso, C. González and D. V. Laurents, Putative One-Pot Prebiotic Polypeptides with Ribonucleolytic Activity, Chem. Eur. J., 16, 5314-5323, 2010. http://doi.org/10.1002/chem.200903207.

- E. Leon, G. Navarro-Aviles, C. M. Santiveri, C. Flores-Flores, M. Rico, C. González, F. J. Murillo, M. Elias-Arnanz, M. Angeles Jimenez and S. Padmanabhan, A bacterial antirepressor with SH3 domain topology mimics operator DNA in sequestering the repressor DNA recognition helix, Nucleic Acids Res., 38, 5226-5241, 2010. http://doi.org/10.1093/nar/gkq277.

- J. Casals, J. Viladoms, E. Pedroso and C. González, Structure and stability of a dimeric g-quadruplex formed by cyclic oligonucleotides, JNA

ID: 468017, 2010. http://doir.org/10.4061/2010/4680172010

- A. Avino, E. Cubero, R. Gargallo, C. González, M. Orozco and R. Eritja, Structural properties of g,t-parallel duplexes, JNA, ID: 763658, 2010. http://dx.doi.org/10.4061/2010/763658

 

2009

- J. Viladoms, N. Escaja, M. Frieden, I. Gomez-Pinto, E. Pedroso and C. González, Self-association of short DNA loops through minor groove C:G:G:C tetrads, Nucleic Acids Res., 37, 3264-3275, 2009. http://doi.org/10.1093/nar/gkp191.

- M. Torrado, J. Revuelta, C. González, F. Corzana, A. Bastida and J. Luis Asensio, Role of Conserved Salt Bridges in Homeodomain Stability and DNA Binding, J. Biol. Chem., 284, 23765-23779, 2009. http://doi.org/10.1074/jbc.M109.012054.

- H. Saneyoshi, S. Mazzini, A. Avino, G. Portella, C. González, M. Orozco, V. E. Marquez and R. Eritja, The use of conformationally rigid nucleoside probes to study the role of sugar pucker and nucleobase orientation in the thrombin binding aptamer, Nucleic acids symposium series (2004), 109-10, 2009.

- H. Saneyoshi, S. Mazzini, A. Avino, G. Portella, C. González, M. Orozco, V. E. Marquez and R. Eritja, Conformationally rigid nucleoside probes help understand the role of sugar pucker and nucleobase orientation in the thrombin-binding aptamer, Nucleic Acids Res., 37, 5589-5601, 2009. http://doi.org/10.1093/nar/gkp598.

- J. P. Lopez-Alonso, F. Diez-Garcia, J. Font, M. Ribo, M. Vilanova, J. M. Scholtz, C. González, F. Vottariello, G. Gotte, M. Libonati and D. V. Laurents, Carbodiimide EDC Induces Cross-Links That Stabilize RNase A C-Dimer against Dissociation: EDC Adducts Can Affect Protein Net Charge, Conformation, and Activity, Bioconjugate Chem., 20, 1459-1473, 2009. http://doi.org/10.1021/bc9001486.

- E. Leon, G. Navarro-Aviles, C. M. Santiveri, C. González, M. Rico, F. J. Murillo, M. Elias-Arnanz, S. Padmanabhan and M. A. Jimenez, Structural bases for antagonistic repressor-operator and repressor-antirepressor interactions in a photo-inducible switch in Myxococcus xanthus, Febs Journal, 276, 143-143, 2009.

- E. Leon, C. González, M. Elias-Arnanz, S. Padmanabhan and M. Angeles Jimenez, H-1, C-13 and N-15 backbone and side chain resonance assignments of a Myxococcus xanthus anti-repressor with no known sequence homologues, Biomol. Nmr Assign., 3, 37-40, 2009. http://doi.org/10.1007/s12104-008-9136-2.

- M. del Toro, P. Bucek, A. Avino, J. Jaumot, C. González, R. Eritja and R. Gargallo, Targeting the G-quadruplex-forming region near the P1 promoter in the human BCL-2 gene with the cationic porphyrin TMPyP4 and with the complementary C-rich strand, Biochimie, 91, 894-902, 2009. http://doi.org/10.1016/j.biochi.2009.04.012.

 

2008

- L. Vela, E. Sevilla, C. González, M. T. Bes, M. F. Fillat and M. L. Peleato, Exploring the interaction of microcystin-LR with proteins and DNA, Toxicology in Vitro, 22, 1714-1718, 2008. http://doi.org/10.1016/j.tiv.2008.07.008.

- J. Revuelta, T. Vacas, M. Torrado, F. Corzana, C. González, J. Jimenez-Barbero, M. Menendez, A. Bastida and J. L. Asensio, NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): The pattern of OH/NH3+ substitution determines the preferred antibiotic binding mode and is critical for drug inactivation, J. Am. Chem. Soc., 130, 5086-5103, 2008. http://doi.org/10.1021/ja076835s.

- D. Pulido, J. P. Lopez-Alonso, V. Marchan, C. González, A. Grandas and D. V. Laurents, Preparation of ribonuclease S domain-swapped dimers conjugated with DNA and PNA: Modulating the activity of ribonucleases, Bioconjugate Chem., 19, 263-270, 2008. http://doi.org/10.1021/bc700374q.

- J. Gros, A. Avino, J. L. de la Osa, C. González, L. Lacroix, A. Perez, M. Orozco, R. Eritja and J.-L. Mergny, 8-amino guanine accelerates tetramolecular G-quadruplex formation, Chem. Commun., 2926-2928, 2008. http://doi.org/10.1039/b801221k.

2007

- G. Navarro-Aviles, M. Angeles Jimenez, M. Cruz Perez-Marin, C. González, M. Rico, F. Jose Murillo, M. Elias-Arnanz and S. Padmanabhan, Structural basis for operator and antirepressor recognition by Myxococcus xanthus CarA repressor, Molecular Microbiology, 63, 980-994, 2007. http://doi.org/10.1111/j.1365-2958.2006.05567.x.

- J. Lopez de la Osa, D. A. Bateman, S. Ho, C. González, A. Chakrabartty and D. V. Laurents, Getting specificity from simplicity in putative proteins from the prebiotic Earth, Proc. Nat. Acad. Sci. USA, 104, 14941-14946, 2007. http://doi.org/10.1073/pnas.0706876104.

- N. Khan, A. Avino, R. Tauler, C. González, R. Eritja and R. Gargallo, Solution equilibria of the i-motif-forming region upstream of the B-cell lymphoma-2 P1 promoter, Biochimie, 89, 1562-1572, 2007. http://doi.org/10.1016/j.biochi.2007.07.026.

- F. Freire, I. Cuesta, F. Corzana, J. Revuelta, C. González, M. Hricovini, A. Bastida, J. Jimenez-Barbero and J. L. Asensio, A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer, Chem. Commun., 174-176, 2007. http://doi.org/10.1039/b611597g.

- N. Escaja, I. Gomez-Pinto, E. Pedroso and C. González, Four-stranded DNA structures can be stabilized by two different types of minor groove G : C : G : C tetrads, J. Am. Chem. Soc., 129, 2004-2014, 2007. http://doi.org/10.1021/ja066172z.

- A. Avino, M. G. Grimau, M. Alvira, R. Eritja, R. Gargallo, M. Orozco and C. Gonzales, Triplex formation using oligonucleotide clamps carrying 8-aminopurines, Nucleosides Nucleotides & Nucleic Acids, 26, 979-983, 2007. http://doi.org/10.1080/15257770701508398.

2006

- J. P. Lopez-Alonso, M. Bruix, J. Font, M. Ribo, M. Vilanova, M. Rico, G. Gotte, M. Libonati, C. González and D. V. Laurents, Formation, structure, and dissociation of the ribonuclease S three-dimensional domain-swapped dimer, J. Biol. Chem., 281, 9400-9406, 2006. http://doi.org/10.1074/jbc.M510491200.

- N. Escaja, I. Gomez-Pinto, J. Viladoms, M. Rico, E. Pedroso and C. González, Induced-fit recognition of DNA by small circular oligonucleotides, Chem. Eur. J, 12, 4035-4042, 2006. http://doi.org/10.1002/chem.200600050.

- J. P. de la Osa, C. González, R. Gargallo, M. Rueda, E. Cubero, M. Orozco, A. Avino and R. Eritja, Destabilization of quadruplex DNA by 8-aminoguanine, Chembiochem, 7, 46-48, 2006. http://doi.org/10.1002/cbic.200500281.

- A. Bastida, A. Hidalgo, J. L. Chiara, M. Torrado, F. Corzana, J. M. Perez-Canadillas, P. Groves, E. Garcia-Junceda, C. González, J. Jimenez-Barbero and J. L. Asensio, Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance, J. Am. Chem. Soc., 128, 100-116, 2006. http://doi.org/10.1021/ja0543144.

- B. Alguero, J. L. de la Osa, C. González, E. Pedroso, V. Marchan and A. Grandas, Selective platination of modified oligonucleotides and duplex cross-links, Angew. Chem. Int. Ed., 45, 8194-8197, 2006. http://doi.org/10.1002/anie.200603128.

2005

- F. Corzana, I. Cuesta, A. Bastida, A. Hidalgo, M. Latorre, C. González, E. Garcia-Junceda, J. Jimenez-Barbero and J. L. Asensio, Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase, Chem. Eur. J, 11, 5102-5113, 2005. http://doi.org/10.1002/chem.200400941.

- J. L. Asensio, A. Albert, D. Munoz-Espin, C. González, J. Hermoso, L. Villar, J. Jimenez-Barbero, M. Salas and W. J. J. Meijer, Structure of the functional domain of phi 29 replication organizer, J. Biol. Chem., 280, 20730-20739, 2005. http://doi.org/10.1074/jbc.M501687200.

2004

- M. Maqueda, A. Galvez, M. M. Bueno, M. J. Sanchez-Barrena, C. González, A. Albert, M. Rico and E. Valdivia, Peptide AS-48: Prototype of a new class of cyclic bacteriocins, Current Protein & Peptide Science, 5, 399-416, 2004. http://doi.org/10.2174/1389203043379567.

- I. Gomez-Pinto, E. Cubero, S. G. Kalko, V. Monaco, G. van der Marel, J. H. van Boom, M. Orozco and C. González, Effect of bulky lesions on DNA - Solution structure of a DNA duplex containing a cholesterol adduct, J. Biol. Chem., 279, 24552-24560, 2004. http://doi.org/10.1074/jbc.M311751200.

- N. G. A. Abrescia, C. González, C. Gouyette and J. A. Subirana, X-ray and NMR studies of the DNA oligomer d(ATATAT): Hoogsteen base pairing in duplex DNA, Biochemistry, 43, 4092-4100, 2004. http://doi.org/10.1021/bi0355140.

2003

- C. González, J. L. Neira, S. Ventura, S. Bronsoms, M. Rico and F. X. Aviles, Structure and dynamics of the potato carboxypeptidase inhibitor by H-1 and N-15 NMR, Proteins-Structure Function and Genetics, 50, 410-422, 2003. http://doi.org/10.1002/prot.10291.

- I. Gomez-Pinto, V. Marchan, F. Gago, A. Grandas and C. González, Solution structure and stability of tryptophan-containing nucleopeptide duplexes, Chembiochem, 4, 40-49, 2003. http://doi.org/10.1002/cbic.200390012.

- I. Gomez-Pinto, V. Marchan, F. Gago, A. Grandas and C. González, Solution structure and stability of a disulfide cross-linked nucleopeptide duplex, Chem. Commun., 2558-2559, 2003. http://doi.org/10.1039/b307300a.

- N. Escaja, I. Gomez-Pinto, M. Rico, E. Pedroso and C. González, Structures and Stabilities of small DNA dumbbells with Watson-Crick and Hoogsteen base pairs, Chembiochem, 4, 623-632, 2003. http://doi.org/10.1002/cbic.200300578.

- N. Escaja, J. L. Gelpi, M. Orozco, M. Rico, E. Pedroso and C. González, Four-stranded DNA structure stabilized by a novel G : C : A : T tetrad, J. Am. Chem. Soc., 125, 5654-5662, 2003. http://doi.org/10.1021/ja0344157.

- A. Avino, M. Frieden, J. C. Morales, B. G. de la Torre, R. Guimil-Garcia, M. Orozco, C. González and R. Eritja, Properties of triple helices formed by oligonucleotides containing 8-amitiopurines, Nucleosides Nucleotides & Nucleic Acids, 22, 645-648, 2003. http://doi.org/10.1081/ncn-120021971.

- A. Avino, E. Cubero, C. González, R. Eritja and M. Orozco, Antiparallel triple helices. Structural characteristics and stabilization by 8-amino derivatives, J. Am. Chem. Soc., 125, 16127-16138, 2003. http://doi.org/10.1021/ja035039t.